HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
A multilayered immune system through the lens of unconventional T cells
The unconventional T cell compartment encompasses a variety of cell subsets that straddle
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis
D Corridoni, A Antanaviciute, T Gupta… - Nature medicine, 2020 - nature.com
Colonic antigen-experienced lymphocytes such as tissue-resident memory CD8+ T cells can
respond rapidly to repeated antigen exposure. However, their cellular phenotypes and the …
respond rapidly to repeated antigen exposure. However, their cellular phenotypes and the …
Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0. 0
CK Hurley, J Kempenich, K Wadsworth, J Sauter… - Hla, 2020 - Wiley Online Library
A catalog of common, intermediate and well‐documented (CIWD) HLA‐A,‐B,‐C,‐DRB1,‐
DRB3,‐DRB4,‐DRB5,‐DQB1 and‐DPB1 alleles has been compiled from over 8 million …
DRB3,‐DRB4,‐DRB5,‐DQB1 and‐DPB1 alleles has been compiled from over 8 million …
Class I HLA haplotypes form two schools that educate NK cells in different ways
A Horowitz, Z Djaoud, N Nemat-Gorgani… - Science …, 2016 - science.org
Natural killer (NK) cells are lymphocytes that have vital functions in innate and adaptive
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) …
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) …
Modulation of innate and adaptive immunity by cytomegaloviruses
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
Killers 2.0: NK cell therapies at the forefront of cancer control
JJ Hodgins, ST Khan, MM Park… - The Journal of …, 2019 - Am Soc Clin Investig
Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …
elimination of cancer. As we have learned more and more about the mechanisms NK cells …
[HTML][HTML] Targeting checkpoint receptors and molecules for therapeutic modulation of natural killer cells
N Kim, HS Kim - Frontiers in immunology, 2018 - frontiersin.org
Among the most promising therapeutic modalities for cancer treatment is the blockade of
immune checkpoint pathways, which are frequently co-opted by tumors as a major …
immune checkpoint pathways, which are frequently co-opted by tumors as a major …
[HTML][HTML] Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond
S Pagliuca, C Gurnari, MT Rubio, V Visconte… - Frontiers in …, 2022 - frontiersin.org
Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …
competent adaptive immune responses against pathogen and tumor antigens as it assures …
Natural killer cell recruitment and activation are regulated by CD47 expression in the tumor microenvironment
Elevated CD47 expression in some cancers is associated with decreased survival and
limited clearance by phagocytes expressing the CD47 counterreceptor SIRPα. In contrast …
limited clearance by phagocytes expressing the CD47 counterreceptor SIRPα. In contrast …