The insulin-like growth factor (IGF) system plays a central role in the neuroendocrine
regulation of growth in all vertebrates. Evidence from studies in a variety of vertebrate …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

The discovery of myostatin and our introduction to the “Mighty Mouse” over a decade ago
spurred both basic and applied research and impacted popular culture as well. The …

Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

The retina of the adult teleost fish is an important model for studying persistent and injury-
induced neurogenesis in the vertebrate central nervous system. All neurons, with the …

Teleost fish are distinguished by their ability to constitutively generate new neurons in the
adult central nervous system ('adult neurogenesis'), and to regenerate whole neurons after …

The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …

The brains of all vertebrates are persistently neurogenic. However, this is not true for the
neural retinas. Only three extant classes of vertebrates show significant posthatch/postnatal …

Neuronal degenerations in the retina are leading causes of blindness. Like most other areas
of the CNS, the neurons of the mammalian retina are not replaced following degeneration …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …