NADPH oxidases: an overview from structure to innate immunity-associated pathologies

A Panday, MK Sahoo, D Osorio, S Batra - Cellular & molecular …, 2015 - nature.com
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Reactive oxygen species in cell signaling

VJ Thannickal, BL Fanburg - American Journal of …, 2000 - journals.physiology.org
Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

NAD (P) H oxidase: role in cardiovascular biology and disease

KK Griendling, D Sorescu, M Ushio-Fukai - Circulation research, 2000 - Am Heart Assoc
Reactive oxygen species have emerged as important molecules in cardiovascular function.
Recent work has shown that NAD (P) H oxidases are major sources of superoxide in …

Cytokines in atherosclerosis: pathogenic and regulatory pathways

A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD (P) H oxidase in cultured …

T Inoguchi, P Li, F Umeda, HY Yu, M Kakimoto… - Diabetes, 2000 - Am Diabetes Assoc
Recent studies have revealed that vascular cells can produce reactive oxygen species
(ROS) through NAD (P) H oxidase, which may be involved in vascular injury. However, the …

[图书][B] Oxidation and antioxidants in organic chemistry and biology

ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Vascular NAD (P) H oxidases: specific features, expression, and regulation

B Lassegue, RE Clempus - American Journal of Physiology …, 2003 - journals.physiology.org
The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology

KK Griendling, D Sorescu, B Lassègue… - … , and vascular biology, 2000 - Am Heart Assoc
Emerging evidence indicates that reactive oxygen species, especially superoxide and
hydrogen peroxide, are important signaling molecules in cardiovascular cells. Their …

Oxidative stress and atherosclerosis

U Singh, I Jialal - Pathophysiology, 2006 - Elsevier
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western
world. Its incidence has been increasing lately in developing countries. Several lines of …

Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and …

K Irani - Circulation research, 2000 - Am Heart Assoc
Reactive oxygen species (ROS) have been traditionally regarded as toxic byproducts of
aerobic metabolism. However, ROS can also act as intracellular signaling molecules in …