Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

Activity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant
neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote …

Abstract STXBP1 and SCN2A gene mutations are observed in patients with epilepsies,
although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for …

In patients suffering absence epilepsy, recurring seizures can significantly decrease their
quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized …

Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and
unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake …

Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …

Flight, an active fear response to imminent threat, is dependent on the rapid risk assessment
of sensory information processed by the cortex. The thalamic reticular nucleus (TRN) filters …

Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …

It is now well established that the bacterial population of the gastrointestinal system, known
as the gut microbiome, is capable of influencing the brain and its dependent functions. Links …