The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …

Protein lipidation is an important co-or posttranslational modification in which lipid moieties
are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth,
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

S-palmitoylation describes the reversible attachment of fatty acids (predominantly palmitate)
onto cysteine residues via a labile thioester bond. This posttranslational modification …

We constructed Drosophila melanogaster bacterial artificial chromosome libraries with 21-
kilobase and 83-kilobase inserts in the P [acman] system. We mapped clones representing …

Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …

Protein palmitoylation is the most common posttranslational lipid modification; its reversibility
mediates protein shuttling between intracellular compartments. A large family of DHHC (Asp …