Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2
Mammalian development requires effective mechanisms to repress genes whose
expression would generate inappropriately specified cells. The Polycomb-repressive …
expression would generate inappropriately specified cells. The Polycomb-repressive …
Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation
The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …
Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
Abstract Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate
gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive …
gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive …
ZMYND11 links histone H3. 3K36me3 to transcription elongation and tumour suppression
H Wen, Y Li, Y Xi, S Jiang, S Stratton, D Peng… - Nature, 2014 - nature.com
Recognition of modified histones by 'reader'proteins plays a critical role in the regulation of
chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the …
chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the …
[HTML][HTML] Structure of an activated DNA-PK and its implications for NHEJ
DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …
Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor κB
S Takashiba, TE Van Dyke, S Amar… - Infection and …, 1999 - Am Soc Microbiol
During infection, circulating blood monocytes migrate from the vasculature to the
extravascular compartments where they mature into tissue macrophages. The maturation …
extravascular compartments where they mature into tissue macrophages. The maturation …
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning
CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …
Asymmetric molecular architecture of the human γ-tubulin ring complex
The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …
Autophosphorylation transforms DNA-PK from protecting to processing DNA ends
The DNA-dependent protein kinase (DNA-PK) initially protects broken DNA ends but then
promotes their processing during non-homologous end joining (NHEJ). Before ligation by …
promotes their processing during non-homologous end joining (NHEJ). Before ligation by …
Acetyl-methyllysine marks chromatin at active transcription start sites
WJ Lu-Culligan, LJ Connor, Y Xie, BE Ekundayo… - Nature, 2023 - nature.com
Lysine residues in histones and other proteins can be modified by post-translational
modifications that encode regulatory information. Lysine acetylation and methylation are …
modifications that encode regulatory information. Lysine acetylation and methylation are …