[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction
V Kalienkova, VC Mosina, C Paulino - Journal of Molecular Biology, 2021 - Elsevier
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …
while some family members function as Ca 2+-activated anion channels, the majority of …
Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity
DI Fernández, MJE Kuijpers, JWM Heemskerk - Platelets, 2021 - Taylor & Francis
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or
ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists …
ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists …
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase
The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …
Structural basis for the activation of the lipid scramblase TMEM16F
TMEM16F, a member of the conserved TMEM16 family, plays a central role in the initiation
of blood coagulation and the fusion of trophoblasts. The protein mediates passive ion and …
of blood coagulation and the fusion of trophoblasts. The protein mediates passive ion and …
Cryo-EM studies of TMEM16F calcium-activated ion channel suggest features important for lipid scrambling
As a Ca 2+-activated lipid scramblase and ion channel that mediates Ca 2+ influx,
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …
Critical role of lipid scramblase TMEM16F in phosphatidylserine exposure and repair of plasma membrane after pore formation
N Wu, V Cernysiov, D Davidson, H Song, J Tang, S Luo… - Cell reports, 2020 - cell.com
Plasma membrane damage and cell death during processes such as necroptosis and
apoptosis result from cues originating intracellularly. However, death caused by pore …
apoptosis result from cues originating intracellularly. However, death caused by pore …
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion
Abstract TMEM16F, a Ca 2+-activated phospholipid scramblase (CaPLSase), is critical for
placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated …
placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated …
Chloride–the underrated ion in nociceptors
BU Wilke, KK Kummer, MG Leitner… - Frontiers in neuroscience, 2020 - frontiersin.org
In contrast to pain processing neurons in the spinal cord, where the importance of chloride
conductances is already well established, chloride homeostasis in primary afferent neurons …
conductances is already well established, chloride homeostasis in primary afferent neurons …
Polymodal control of TMEM16x channels and scramblases
E Agostinelli, P Tammaro - International Journal of Molecular Sciences, 2022 - mdpi.com
The TMEM16A/anoctamin-1 calcium-activated chloride channel (CaCC) contributes to a
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
Gating and regulatory mechanisms of TMEM16 ion channels and scramblases
The transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels
and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop …
and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop …