The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
Chromatin ubiquitination Guides DNA double strand break signaling and repair
KG Kolobynina, A Rapp, MC Cardoso - Frontiers in Cell and …, 2022 - frontiersin.org
Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …
nucleus. The initial chromatin structure at the site of the DNA damage determines both …
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3 ligase, has
a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of …
a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of …
Chemical protein synthesis enabled mechanistic studies on the molecular recognition of K27‐linked ubiquitin chains
M Pan, Q Zheng, S Ding, L Zhang, Q Qu… - Angewandte Chemie …, 2019 - Wiley Online Library
New synthetic strategies that exploited the strengths of both chemoselective ligation and
recombinant protein expression were developed to prepare K27 di‐ubiquitins (diUb), which …
recombinant protein expression were developed to prepare K27 di‐ubiquitins (diUb), which …
Structural basis of specific H2A K13/K15 ubiquitination by RNF168
V Horn, M Uckelmann, H Zhang, J Eerland… - Nature …, 2019 - nature.com
Ubiquitination of chromatin by modification of histone H2A is a critical step in both regulation
of DNA repair and regulation of cell fate. These very different outcomes depend on the …
of DNA repair and regulation of cell fate. These very different outcomes depend on the …
[HTML][HTML] Mechanisms of RNF168 nucleosome recognition and ubiquitylation
RNF168 plays a central role in the DNA damage response (DDR) by ubiquitylating histone
H2A at K13 and K15. These modifications direct BRCA1-BARD1 and 53BP1 foci formation …
H2A at K13 and K15. These modifications direct BRCA1-BARD1 and 53BP1 foci formation …
Promotion of RNF168‐Mediated Nucleosomal H2A Ubiquitylation by Structurally Defined K63‐Polyubiquitylated Linker Histone H1
The chemical synthesis of histones with homogeneous modifications is a powerful approach
for quantitatively deciphering the functional crosstalk between different post‐translational …
for quantitatively deciphering the functional crosstalk between different post‐translational …
Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
Y Sato, H Tsuchiya, A Yamagata, K Okatsu… - Nature …, 2019 - nature.com
Npl4 is likely to be the most upstream factor recognizing Lys48-linked polyubiquitylated
substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a …
substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a …
Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites
A Sherker, N Chaudhary, S Adam, AM Heijink… - EMBO …, 2021 - embopress.org
The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐
dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 …
dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 …
New answers to the old RIDDLE: RNF168 and the DNA damage response pathway
J Kelliher, G Ghosal, JWC Leung - The FEBS journal, 2022 - Wiley Online Library
The chromatin‐based DNA damage response pathway is tightly orchestrated by histone
post‐translational modifications, including histone H2A ubiquitination. Ubiquitination plays …
post‐translational modifications, including histone H2A ubiquitination. Ubiquitination plays …