Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …

In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided
degradation of messenger RNA transcripts, has had an important impact on identifying and …

Ewing sarcoma is an aggressive paediatric cancer of the bone and soft tissue. It results from
a chromosomal translocation, predominantly t (11; 22)(q24: q12), that fuses the N-terminal …

We report the construction and analysis of 4,836 heterozygous diploid deletion mutants
covering 98.4% of the fission yeast genome providing a tool for studying eukaryotic biology …

Background Aging is a fundamental biological process. Characterization of genetic and
environmental factors that influence lifespan is a crucial step toward understanding the …

Because spontaneous mutation is the source of all genetic diversity, measuring mutation
rates can reveal how natural selection drives patterns of variation within and between …

RNA interference (RNAi) is an effective tool for genome-scale, high-throughput analysis of
gene function. In the past five years, a number of genome-scale RNAi high-throughput …

The numerous processes that damage DNA are counterbalanced by a complex network of
repair pathways that, collectively, can mend diverse types of damage. Insights into these …

Epithelial ovarian cancer is a highly lethal and aggressive gynecological malignancy. The
high mortality rate is due in part to the fact that many advanced cancer patients become …

DNA repair declines with age and correlates with longevity in many animal species. In this
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …