Undiscovered roles for transthyretin: from a transporter protein to a new therapeutic target for Alzheimer's disease

T Gião, J Saavedra, E Cotrina, J Quintana… - International journal of …, 2020 - mdpi.com
Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …

The role of transthyretin in cell biology: impact on human pathophysiology

J Magalhães, J Eira, MA Liz - Cellular and Molecular Life Sciences, 2021 - Springer
Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid
plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body …

Insulin-like growth factor-1 supplementation promotes brain maturation in preterm pigs

LI Christiansen, B Holmqvist, X Pan, K Holgersen… - eneuro, 2023 - eneuro.org
Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is
associated with postnatal growth restriction and poor neurologic outcomes. It remains …

Transthyretin attenuates TDP-43 proteinopathy by autophagy activation via ATF4 in FTLD-TDP

YP Chu, LW Jin, LC Wang, PC Ho, WY Wei, KJ Tsai - Brain, 2023 - academic.oup.com
Abstract TAR DNA-binding protein-43 (TDP-43) proteinopathies are accompanied by the
pathological hallmark of cytoplasmic inclusions in the neurodegenerative diseases …

[HTML][HTML] Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner

A Zawiślak, P Jakimowicz, JA McCubrey, D Rakus - Oncotarget, 2017 - ncbi.nlm.nih.gov
It has been shown that neurons alter the expression of astrocytic metabolic enzymes by
secretion of until now unknown molecule (s) into extracellular fluid. Here, we present …

Differential gene expression profiling implicates altered network development in rat postnatal day 4 cortex following 4-Methylimidazole (4-MeI) induced maternal …

AJ Massri, M Fitzpatrick, H Cunny, JL Li… - Neurotoxicology and …, 2023 - Elsevier
Compromised maternal health leading to maternal seizures can have adverse effects on the
healthy development of offspring. This may be the result of inflammation, hypoxia-ischemia …

[PDF][PDF] In children with short stature, the effect of serum zinc levels on anthropometric measurements and growth factors

A Ata, DG Taşkın - Jour Umraniye Pediatr, 2023 - academia.edu
Objective: We aim to investigate the relationship between prealbumin, Zinc (Zn), and
somatomedin-C (IGF-1) levels in pediatric patients who presented with short stature and did …

Effects of moxibustion on the levels of insulin-like growth factor 1: A pilot study

JG Lin, SZ Lin, LH Lin, CC Wu, WT Tsai… - Cell …, 2018 - journals.sagepub.com
Moxibustion (艾灸) is a traditional Chinese medicine therapy performed using Artemisia
argyii. Zusanli (足三里, ST36) is an acupoint in the stomach meridian, long associated in …

[PDF][PDF] Ο ρόλος των τροφικών παραγόντων και μορίων μεσοκυττάριας ουσίας στην αναγέννηση επιθηλιακών κυττάρων των νεφρικών σωληναρίων: πειραματικό πρότυπο …

Η Μηνασίδης - 2020 - ikee.lib.auth.gr
2.1. 2. Οξειδωτικό στρες-Μιτοχονδριακή δυσλειτουργία 14 2.1. 3. Νιτρώδη και μονοξείδιο του
αζώτου (NO) 15 2.1. 4. Σύστημα ρενίνης-αγγειοτενσίνης 17 2.1. 5. Το σύστημα του …

Vascular Alterations in Alzheimer's Disease-Role of Aß Peptide and Transthyretin?

TAB Gião - 2019 - search.proquest.com
Na Doença de Alzheimer (DA), a barreira hematoencefálica (BHE) é disfuncional,
contribuindo para a acumulação do péptido β-amilóide (Aβ) no cérebro. Além disso, a …