Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview

MF Lindberg, L Meijer - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Research progress of hexokinase 2 in inflammatory-related diseases and its inhibitors

J Chen, G Li, D Sun, H Li, L Chen - European Journal of Medicinal …, 2024 - Elsevier
Abstract Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts
glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 …

Potential prognostic biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) family members in breast cancer

G Anuraga, WJ Wang, NN Phan, NT An Ton… - Journal of personalized …, 2021 - mdpi.com
Breast cancer remains the most common malignant cancer in women, with a staggering
incidence of two million cases annually worldwide; therefore, it is crucial to explore novel …

The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases

AV Jacobsen, JM Murphy - Biochemical Society Transactions, 2017 - portlandpress.com
Over the past decade, our understanding of the mechanisms by which pseudokinases,
which comprise∼ 10% of the human and mouse kinomes, mediate signal transduction has …

Phosphoproteomics to characterize host response during influenza A virus infection of human macrophages

S Söderholm, DE Kainov, T Öhman… - Molecular & cellular …, 2016 - ASBMB
Influenza A viruses cause infections in the human respiratory tract and give rise to annual
seasonal outbreaks, as well as more rarely dreaded pandemics. Influenza A viruses become …

Human microRNAs profiling in response to influenza A viruses (subtypes pH1N1, H3N2, and H5N1)

J Makkoch, W Poomipak… - Experimental …, 2016 - journals.sagepub.com
MicroRNAs (miRNAs) play an important role in regulation of gene silencing and are involved
in many cellular processes including inhibition of infected viral replication. This study …

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

M Yamamoto, H Onogi, I Kii, S Yoshida… - The Journal of …, 2014 - Am Soc Clin Investig
A wide range of antiviral drugs is currently available; however, drug-resistant viruses have
begun to emerge and represent a potential public health risk. Here, we explored the use of …

miRNA-based strategy for modulation of influenza A virus infection

M Keshavarz, H Dianat-Moghadam, VH Sofiani… - …, 2018 - Taylor & Francis
Influenza A virus is known worldwide as a threat associated with human and livestock
diseases. Hence, identification of physiological and molecular aspects of influenza A could …

[HTML][HTML] Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer

SC Ku, HL Liu, CY Su, IJ Yeh, MC Yen… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Breast cancer is one of the leading deaths in all kinds of malignancies; therefore, it is
important for early detection. At the primary tumor site, tumor cells could take on …

MicroRNA-34/449 family and viral infections

J Lv, Z Zhang, L Pan, Y Zhang - Virus research, 2019 - Elsevier
MicroRNAs are short, endogenous, nonprotein-coding RNAs that are essential for regulation
of cellular processes through gene silencing. The miR-34/449 family is conserved in …