The development of highly selective and sensitive analytical techniques has been a driving
force for unprecedented advances in biotechnology, gene engineering, and drug discovery …

Identifying protein binders is the first step in drug discovery. The combinatorial approach, in
which a library of compounds is subjected to affinity screening against a target protein, is a …

Self‐repairing coatings have received widespread attention due to their ability to repair
damaged surfaces. However, film‐forming molecules can only be fixed on the metal surface …

Selection of aptamers from oligonucleotide libraries currently requires multiple rounds of
alternating steps of partitioning of binders from nonbinders and enzymatic amplification of all …

Partitioning of protein–DNA complexes from protein-unbound DNA is a key step in selection
of DNA aptamers. Conceptually, the partitioning step is characterized by two parameters …

Screening molecular libraries for ligands capable of binding proteins is widely used for hit
identification in the early drug discovery process. Oligonucleotide libraries provide a very …

Selection of target-binding ligands from DNA-encoded libraries of small molecules
(DELSMs) is a rapidly developing approach in drug-lead discovery. Methods of kinetic …

Electrokinetic techniques, such as electrophoresis, electroextraction, and electrodialysis,
have found a wide range of applications in fields such as chemical engineering, chemistry …

Kinetic capillary electrophoresis (KCE) methods are useful in the study of kinetics and
equilibrium properties of interactions between DNA and its binding partners (ligands). KCE …

Selection of affinity ligands for protein targets from oligonucleotide libraries currently
involves multiple rounds of alternating steps of partitioning of protein‐bound …