Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
Long-term maturation of human cortical organoids matches key early postnatal transitions
Human stem-cell-derived models provide the promise of accelerating our understanding of
brain disorders, but not knowing whether they possess the ability to mature beyond mid-to …
brain disorders, but not knowing whether they possess the ability to mature beyond mid-to …
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
Highlights•Stress and depression are characterized by loss of synapses in prefrontal
cortex.•Rapid acting antidepressants increase synaptic contacts in prefrontal cortex.•NMDA …
cortex.•Rapid acting antidepressants increase synaptic contacts in prefrontal cortex.•NMDA …
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
GE Hardingham, KQ Do - Nature Reviews Neuroscience, 2016 - nature.com
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
GRIN2A-related disorders: genotype and functional consequence predict phenotype
Alterations of the N-methyl-d-aspartate receptor (NMDAR) subunit GluN2A, encoded by
GRIN2A, have been associated with a spectrum of neurodevelopmental disorders with …
GRIN2A, have been associated with a spectrum of neurodevelopmental disorders with …
[HTML][HTML] Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes
PS Baxter, GE Hardingham - Free Radical Biology and Medicine, 2016 - Elsevier
The human brain generally remains structurally and functionally sound for many decades,
despite the post-mitotic and non-regenerative nature of neurons. This is testament to the …
despite the post-mitotic and non-regenerative nature of neurons. This is testament to the …
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
PJ Harrison, DM Bannerman - Molecular psychiatry, 2023 - nature.com
Involvement of the glutamate system, particularly N-methyl-D-aspartate (NMDA) receptor
hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia …
hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …