The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

Sequence and copy number variations in the human CFHR–Factor H gene cluster
comprising the complement genes CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, and Factor H …

Age-related macular degeneration (AMD) is one of the most common causes of visual
impairment in the elderly, with a complex and still poorly understood etiology. Whole …

Persistent inflammation is a hallmark of many human diseases, including anti-neutrophil
cytoplasmic antibody-associated vasculitis (AAV) and atherosclerosis. Here, we describe a …

The alternative pathway is a continuously active surveillance arm of the complement system,
and it can also enhance complement activation initiated by the classical and the lectin …

Components of the extracellular matrix (ECM), when exposed to body fluids may promote
local complement activation and inflammation. Pathologic complement activation at the …

Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system,
which is associated with different diseases, such as age-related macular degeneration …

Complement is an evolutionarily conserved system which is important in the defense against
microorganisms and also in the elimination of modified or necrotic elements of the body …

Background Factor H-related protein 5 (FHR-5) is a member of the complement Factor H
protein family. Due to the homology to Factor H, the main complement regulator of the …