BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence
of approximately 2 percent. A pattern of familial aggregation has been documented for the …

Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …

Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie).
Although the formation of PrPSc from the cellular prion protein (PrPC) is a post-translational …

Recent evidence indicates that diverse neurodegenerative diseases might have a common
cause and pathological mechanism—the misfolding, aggregation and accumulation of …

Many non-infectious neurodegenerative diseases are associated with the accumulation of
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …

Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …

SB Prusiner proposed that the infectious agent of scrapie, the prion, is PrP Sc, a modified
form of the normal host protein PrP c. Prn-p 0/0 mice devoid of PrP c showed normal …

Prions are proteins that acquire alternative conformations that become self-propagating.
Transformation of proteins into prions is generally accompanied by an increase in β-sheet …