Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

CR Kahn, G Wang, KY Lee - The Journal of clinical …, 2019 - Am Soc Clin Investig
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126

W Liu, L Li, Y Rong, D Qian, J Chen, Z Zhou, Y Luo… - Acta biomaterialia, 2020 - Elsevier
Increasing evidence has suggested that paracrine mechanisms might be involved in the
underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes …

microRNAs biogenesis, functions and role in tumor angiogenesis

T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

CS Abhinand, R Raju, SJ Soumya, PS Arya… - Journal of cell …, 2016 - Springer
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions
associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2 …

miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis …

Q Qu, L Liu, Y Cui, H Liu, J Yi, W Bing, C Liu… - Stem cell research & …, 2022 - Springer
Background In our previous research, we found that overexpression of miR-126-3p in
human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells …

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma

T Sasahira, T Kirita - International journal of molecular sciences, 2018 - mdpi.com
Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …