Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

Here, we describe a role for mammalian DNA methyltransferases (DNMTs) in telomere
length control. Mouse embryonic stem (ES) cells genetically deficient for DNMT1, or both …

Epigenetic changes to chromatin are thought to be essential to cell senescence, which is
key to tumorigenesis and aging. Although many studies focus on heterochromatin gain, this …

Aging is a multifaceted process characterized by genetic and epigenetic changes in the
genome. The genetic component of aging received initially all of the attention. Telomere …

A‐type lamins are intermediate filament proteins that provide a scaffold for protein
complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked …