The final step of biomineralization is a chemical precipitation reaction that occurs
spontaneously in supersaturated or metastable salt solutions. Genetic programs direct …

Vitamin K acts as a coenzyme of carboxylase, catalyzing the carboxylation of several vitamin
K dependent proteins. Beyond its well-known effects on blood coagulation, it also exerts …

Vascular mineralization has recently emerged as a risk factor for cardiovascular morbidity
and mortality. Previously regarded as a passive end-stage process, vascular mineralization …

BACKGROUND: Matrix vesicles have been implicated in the mineralization of calcified
cartilage, bone and dentin for more than 40 years. During this period, their exact role, if any …

Among the proteins involved in vascular calcium metabolism, the vitamin K-dependent
matrix Gla-protein (MGP) plays a dominant role. Although on a molecular level its …

The mechanisms for vascular calcification and its associated cardiovascular mortality in
patients with ESRD are not completely understood. Dialysis patients exhibit profound …

Objective—Matrix γ-carboxyglutamic acid (Gla) protein (MGP), a vitamin K–dependent
protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low …

Matrix γ-carboxyglutamate (Gla) protein (MGP) is an important local inhibitor of vascular
calcification, which can undergo two post-translational modifications: vitamin K-dependent γ …

Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …

Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires
carboxylation by vitamin K to exert calcification inhibition. Chronic kidney disease (CKD) …