Hepatic stellate cells as key target in liver fibrosis
T Higashi, SL Friedman, Y Hoshida - Advanced drug delivery reviews, 2017 - Elsevier
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …
than one million deaths annually via development of cirrhosis, although no antifibrotic …
On the dependency of cellular protein levels on mRNA abundance
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …
importance for basic and translational life science research and has been studied by …
Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states
P Ma, HM Amemiya, LL He, SJ Gandhi, R Nicol… - Cell, 2023 - cell.com
We introduce BacDrop, a highly scalable technology for bacterial single-cell RNA
sequencing that has overcome many challenges hindering the development of scRNA-seq …
sequencing that has overcome many challenges hindering the development of scRNA-seq …
[HTML][HTML] Fundamental behaviors emerge from simulations of a living minimal cell
ZR Thornburg, DM Bianchi, TA Brier, BR Gilbert… - Cell, 2022 - cell.com
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell
with a reduced genome of 493 genes that has retained few regulatory proteins or small …
with a reduced genome of 493 genes that has retained few regulatory proteins or small …
Self-protected DNAzyme walker with a circular bulging DNA shield for amplified imaging of miRNAs in living cells and mice
Y Gao, S Zhang, C Wu, Q Li, Z Shen, Y Lu, ZS Wu - ACS nano, 2021 - ACS Publications
Abnormal expression of miRNAs is often detected in various human cancers. DNAzyme
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …
[HTML][HTML] “Structure”-function relationships in eukaryotic transcription factors: the role of intrinsically disordered regions in gene regulation
Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …
mechanisms of eukaryotic transcription. However, stark structural and functional differences …
Droplet-based high-throughput single microbe RNA sequencing by smRandom-seq
Bacteria colonize almost all parts of the human body and can differ significantly. However,
the population level transcriptomics measurements can only describe the average bacteria …
the population level transcriptomics measurements can only describe the average bacteria …
Tissue-based map of the human proteome
INTRODUCTION Resolving the molecular details of proteome variation in the different
tissues and organs of the human body would greatly increase our knowledge of human …
tissues and organs of the human body would greatly increase our knowledge of human …
Schrödinger's microbes: tools for distinguishing the living from the dead in microbial ecosystems
While often obvious for macroscopic organisms, determining whether a microbe is dead or
alive is fraught with complications. Fields such as microbial ecology, environmental health …
alive is fraught with complications. Fields such as microbial ecology, environmental health …
Revealing the vectors of cellular identity with single-cell genomics
Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …