Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

Disruption of the tight junctions (TJs) of the blood–brain barrier (BBB) is a hallmark of many
CNS pathologies, including stroke, HIV encephalitis, Alzheimer's disease, multiple sclerosis …

Darier disease (DD) is an autosomal-dominant skin disorder characterized by loss of
adhesion between epidermal cells (acantholysis) and abnormal keratinization. Recently we …

Spermatogenesis is an intriguing but complicated biological process. However, many
studies since the 1960s have focused either on the hormonal events of the hypothalamus …

The blood–brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of
endothelial cells, maintains homeostasis of the brain. Disrupted intracellular Ca2+ …

The expression of the monocyte chemoattractant protein-1 (MCP-1) receptor CCR2 by brain
endothelial cells suggests that MCP-1 may have other functions than purely driving …

Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …

Polarized epithelial cells separate two extremely different cellular milieus. The tight junction
(TJ) is the most apical component of the junctional complex and serves as the permeability …

Background—This review deals with the role of calcium in endothelial cell junctions of the
blood-brain barrier (BBB). Calcium is critical for adherens junction function, but it appears …

Desmosomes are intercellular adhesive junctions that anchor intermediate filaments at
membrane-associated plaques in adjoining cells, thereby forming a three-dimensional …