Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic
stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis …

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

The ubiquitin-proteasome system has numerous crucial roles in physiology and
pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases …

We analyzed the mutational hotspot region of SRSF2 (Pro95) in 275 cases with chronic
myelomonocytic leukemia (CMML). In addition, ASXL1, CBL, EZH2, JAK2 V617F, KRAS …

Somatically acquired genetic abnormalities lead to the salient features that define
myelodysplastic syndromes (MDS): clonal hematopoiesis, aberrant differentiation …

RAS signaling plays a key role in controlling appropriate cell responses to extracellular
stimuli and participates in early and late developmental processes. Although enhanced flow …

The development of acute myeloid leukemia (AML) is a multistep process that requires at
least two genetic abnormalities for the development of the disease. The identification of …

SRSF2, SF3B1, and U2AF35 (U2AF1) are the three most frequent genes involved with
spliceosome mutations in myeloid malignancies. SF3B1 mutations are most frequent …

Progression of chronic myelogenous leukemia (CML) to accelerated (AP) and blast phase
(BP) is because of secondary molecular events, as well as additional cytogenetic …

Several different mutations collaborate with the fusion proteins in core-binding factor acute
myeloid leukemia (CBF-AML) to induce leukemogenesis, but their prognostic significance …