Illuminating function of the understudied druggable kinome
The human kinome, with more than 500 proteins, is crucial for cell signaling and disease.
Yet, about one-third of kinases lack in-depth study. The Data and Resource Generating …
Yet, about one-third of kinases lack in-depth study. The Data and Resource Generating …
Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents
D Nasser Binjawhar, FA Al-Salmi, MA Alghamdi… - ACS …, 2024 - ACS Publications
A new series of cinnamide-fluorinated derivatives has been synthesized and characterized
by using different spectroscopic and elemental microanalyses methods. All of the prepared p …
by using different spectroscopic and elemental microanalyses methods. All of the prepared p …
Determining the most relevant crystal structure to virtually identify type 1 inhibitors of c-Met: Part A
K Begwani, U Joshi - 2024 - nopr.niscpr.res.in
c-Met is a receptor tyrosine kinase, which plays a crucial role in cell proliferation, migration
and angiogenesis. Its dysregulation results in aberrant signalling, resulting in tumor growth …
and angiogenesis. Its dysregulation results in aberrant signalling, resulting in tumor growth …
Determining the Most Relevant Crystal Structure to Virtually Identify Type 1 Inhibitors of c-Met: Part A
U Joshi, K Begwani - Indian Journal of Chemistry (IJC), 2024 - or.niscpr.res.in
Abstract c-Met is a receptor tyrosine kinase, which plays a crucial role in cell proliferation,
migration and angiogenesis. Its dysregulation results in aberrant signalling, resulting in …
migration and angiogenesis. Its dysregulation results in aberrant signalling, resulting in …
[PDF][PDF] Design and Discovery of Silmitasertib-based Drugs as a Potential Casein Kinase II Inhibitor for Cholangiocarcinoma through Hybrid In-silico Ligand-Based …
This research investigates the design and discovery of silmitasertib-based drugs as potential
inhibitors of casein kinase II (CK2) for cholangiocarcinoma using hybrid in-silico methods …
inhibitors of casein kinase II (CK2) for cholangiocarcinoma using hybrid in-silico methods …