The capacity to adjust food intake in response to changing energy requirements is essential
for survival. Recent progress has provided an insight into the molecular, cellular and …

The brain, particularly the hypothalamus, integrates input from factors that stimulate
(orexigenic) and inhibit (anorexigenic) food intake. In fish, the identification of appetite …

Leptin, the protein product of the obese (ob or Lep) gene, is a hormone synthesized by
adipocytes that signals available energy reserves to the brain, and thereby influences …

To assess the role of leptin on food intake regulation in goldfish, we examined the effects of
central (intracerebroventricular, ICV) and peripheral (intraperitoneal, IP) injections of …

In this sweeping exploration of the relatively recent obesity epidemic, Michael L. Power and
Jay Schulkin probe evolutionary biology, history, physiology, and medical science to …

The production of peptide hormones by skeletal muscle tissue is a promising area of gene
therapy. Skeletal muscle myogenesis can be induced in vitro, resulting in the fusion of …

We identified cDNA coding for a homologue to mammalian leptin in puffer, Takifugu
rubripes, using genomic synteny around the human leptin gene. In addition to significant …

Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin …

Classical studies of vertebrate physiology have usually been confined to a given organ or
cell type. The use of mouse genetics has changed this approach and has rejuvenated the …

In fish, as in all vertebrates, the brain is the primary center of regulation of food intake.
Afferent signals continuously inform the central nervous system about changes in energy …