Selective control of transposable element expression during T cell exhaustion and anti–PD-1 treatment

PE Bonté, C Metoikidou, S Heurtebise-Chretien… - Science …, 2023 - science.org
In chronic infections and cancer, T cells are exposed to prolonged antigen stimulation,
resulting in loss of function (or exhaustion) and impairment of effective immunological …

Inhibition of EZH2 causes retrotransposon derepression and immune activation in porcine lung alveolar macrophages

L Zhang, J Jin, W Qin, J Jiang, W Bao… - International Journal of …, 2023 - mdpi.com
Alveolar macrophages (AMs) form the first defense line against various respiratory
pathogens, and their immune response has a profound impact on the outcome of respiratory …

Positive selection and duplication of bat TRIM family proteins

J Xie, B Tan, Y Zhang - Viruses, 2023 - mdpi.com
Bats have received increasing attention because of some unique biological features they
possess. TRIM is a large family of proteins that participate in diverse cellular functions, such …

IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses

PC De La Cruz-Rivera, JL Eitson, JW Schoggins - bioRxiv, 2024 - biorxiv.org
Bats are considered unique in their ability to harbor large numbers of viruses and serve as
reservoirs for zoonotic viruses that have the potential to spill over into humans. However …

Unraveling transposable element-mediated regulatory landscape in diverse human immune cells

C Du, H Fan, J Jiang, J Yang, S Chen, NE Vorobyeva… - bioRxiv, 2024 - biorxiv.org
Transposable elements (TEs) are key contributors to genetic novelty. Despite increasing
evidence of their importance, their roles in shaping the regulatory landscape of diverse …