Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells
has led to the development of established GLP-1R-based therapies for the long-term …

Objective Pathogenic variants in KCNB1, encoding the voltage‐gated potassium channel
KV2. 1, are associated with developmental and epileptic encephalopathy (DEE). Previous …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by a progressive loss of lower motor neurons in the spinal cord. The incretin …

Voltage-gated potassium ion channels (Kv) play an important role in a variety of cellular
processes, including the functioning of excitable cells, regulation of apoptosis, cell growth …

Key points The gut hormone called glucagon‐like peptide 1 (GLP‐1) is a strong moderator
of energy homeostasis and communication between the peripheral organs and the brain …

Lysine acetylation is a reversible post-translational modification (PTM) which has been
linked to many biological and pathological implications. Hence, localization of lysine …

Ethnopharmacological relevance Catharanthus roseus (L). Don (Catharanthus roseus) is a
traditional anti-diabetic herb widely used in many countries, and the alkaloids of …

Transient Receptor Potential Canonical (TRPC) channels are homologues of Drosophila
TRP channel first cloned in mammalian cells. TRPC family consists of seven members which …

Glucose‐dependent insulinotropic polypeptide (GIP) was the first incretin to be identified. In
addition to stimulating insulin secretion, GIP plays regulatory roles in the maintenance …