Pain is the leading cause of medical consultations and occurs in 50–70% of emergency
department visits. To date, several drugs have been used to manage pain. The clinical use …

Background Dexmedetomidine (DEX), a centrally acting alpha‐2 agonist, is increasingly
used for sedation in multiple clinical settings. Evidence from the intensive care unit and …

Introduction The combination of different agents used for procedural sedation allows a
greater range of desirable effects while minimizing side effects. The ketamine …

Background Recently, drug combination protocols have been preferred over single drugs in
procedural sedation and analgesia (PSA). This study aimed to compare the effectiveness …

This retrospective observational study evaluated the safety and efficacy of the ketamine and
dexmedetomidine combination (keta-dex) compared to ketamine or dexmedetomidine alone …

Abstract Purpose of Review The combination of ketamine with propofol and
dexmedetomidine has gained popularity for sedation and general anesthesia in different …

Introduction: Studies have suggested dexmedetomidine (DEX) as a potential
antidepressant. However, no relevant research exists on its effects and mechanisms in …

Background We aimed to evaluate the comparative effectiveness and safety of various iv
pharmacologic agents used for procedural sedation and analgesia (PSA) in the emergency …

Background: As endoscopy is an invasive and painful procedure, it is necessary to use a
suitable sedative with a minimum dose, especially in children. Objectives: This study aimed …

Objective To compare the efficacy and safety of ketamine alone with those of ketamine‐
dexmedetomidine combination for sedation during brain CT in paediatric patients with head …