The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

The tumor suppressor p53 is lost or mutated in about half of all human cancers, and in those
tumors in which it is wild-type, mechanisms exist to prevent its activation. p53 loss not only …

Abstract 'Breast cancer gene-expression miner'(bc-GenExMiner) is a breast cancer–
associated web portal (http://bcgenex. ico. unicancer. fr). Here, we describe the development …

Functional studies giving insight into the biology of circulating tumor cells (CTC s) remain
scarce due to the low frequency of CTC s and lack of appropriate models. Here, we describe …

Germline pathogenic variants in TP53 gene have different consequences according to cell,
tissue, context and age. The occurrence of frequent variants in patients with no criteria …

Breast and ovarian cancers are the second and fifth leading causes of cancer deaths among
women. Both breast and ovarian cancers are highly heterogeneous and are presented with …

Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here,
we report that gain-of-function mutant p53 proteins inhibit the autophagic pathway favoring …

Chemotherapy and radiation often induce a number of cellular responses, such as
apoptosis, autophagy, and senescence. One of the major regulators of these processes is …

Background MDM2/MDMX proteins are frequently elevated in hormone receptor-positive
(ER+) breast cancer. We sought to determine the antitumor efficacy of the combination of …

Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes
cancer cell malignancy. To provide a better understanding of the biological processes …