Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …

Introduction Thermo transient receptor potential (thermoTRP) channels are some of the most
intensely pursued therapeutic targets of the past decade. They are considered promising …

The heart is a mechanically-active organ that dynamically senses its own mechanical
environment. This environment is constantly changing, on a beat-by-beat basis, with …

Abstract Aims Cardiomyocyte Ca2+ homeostasis is altered with aging via poorly-understood
mechanisms. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an …

RNA binding proteins represent an emerging class of proteins with a role in cardiac
dysfunction. We show that activation of the RNA binding protein human antigen R (HuR) is …

Calcium is an important second messenger in cardiac function. It is not only critical for the
excitationcontraction coupling and relaxation of the heart (Bers, 2002), but it is also …

The available pharmacological options in the management of cardiovascular diseases such
as ischaemic heart disease and subsequent heart failure are effective in slowing the …