Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Cachexia remains an underdiagnosed and undertreated, complex condition which includes
'objective'components (eg inadequate food intake, weight loss, inactivity, loss of muscle …

Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …

Background Cancer cachexia is a progressive and multi-factorial metabolic syndrome
characterized by loss of adipose tissue and skeletal muscle. White adipose tissue (WAT) …

Global rates of obesity continue to rise and are necessarily the consequence of a long-term
imbalance between energy intake and energy expenditure. This is the result of an …

Adipose tissue is a dynamic organ, well known for its function in energy storage and
mobilization according to nutrient availability and body needs, in charge of keeping the …

Adaptation to changes in energy availability is pivotal for the survival of animals. Adipose
tissue, the body's largest reservoir of energy and a major source of metabolic fuel, exerts a …

Cancer cachexia is a complex disorder that is driven by inflammation and metabolic
imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer …

Cachexia represents a fatal energy-wasting syndrome in a large number of patients with
cancer that mostly results in a pathological loss of skeletal muscle and adipose tissue. Here …