Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …

Artificial metalloenzymes have emerged as an attractive new approach to enantioselective
catalysis. Herein, we introduce a novel strategy for preparation of artificial metalloenzymes …

Genetic code expansion is a promising genetic engineering technology that incorporates
noncanonical amino acids into proteins alongside the natural set of 20 amino acids. This …

Phosphine ligands are the most important class of ligands for cross-coupling reactions due
to their unique electronic and steric properties. However, metalloproteins generally rely on …

Highlights•Metal–peptide hybrids have unique potential for catalysis.•Unnatural amino acids
(UAAs) can be used to create novel hybrid catalysts.•Several methods have been developed …

More than one third of all proteins are metalloproteins. They catalyze important reactions
such as photosynthesis, nitrogen fixation and CO2 reduction. Metalloproteins such as the …

Grund zum Erröten: Eine chelatbildende nichtnatürliche Aminosäure mit einer 8‐
Hydroxychinolin‐Gruppe (HqAla) kann enzymatisch in FPs eingebaut werden. Die …

Formaldehyde (FA) is endogenously produced in living systems through a variety of
biological processes and has been implicated in many pathological conditions. Detection …