Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

Transcription factor networks in cellular quiescence

M Mitra, SL Batista, HA Coller - Nature Cell Biology, 2025 - nature.com
Many of the cells in mammalian tissues are in a reversible quiescent state; they are not
dividing, but retain the ability to proliferate in response to extracellular signals. Quiescence …

Alternative pre-mRNA splicing in stem cell function and therapeutic potential: A critical review of current evidence

L Cui, Y Zheng, R Xu, Y Lin, J Zheng, P Lin… - International Journal of …, 2024 - Elsevier
Alternative splicing is a crucial regulator in stem cell biology, intricately influencing the
functions of various biological macromolecules, particularly pre-mRNAs and the resultant …

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

P Jiménez Peinado, A Urbach - Cells, 2023 - mdpi.com
Since Joseph Altman published his pioneering work demonstrating neurogenesis in the
hippocampus of adult rats, the number of publications in this field increased exponentially …

Characterization of small RNAs in the spleen of MASH in a non-human primate model

J Zhao, Y Zhao, H Qin, Y Ye, L Zhang, R Ding, W Cao… - Genomics, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced stage,
metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as a …

Faecal microbiota transplantation from Alzheimer's participants induces impairments in neurogenesis and cognitive behaviours in rats

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - bioRxiv, 2022 - biorxiv.org
The gut microbiome is emerging as an important susceptibility factor in Alzheimer's disease
(AD) possibly due to the increased prevalence of pro-inflammatory genera in gut microbiota …

Cerebellar granular neuron progenitors exit their germinative niche via Barhl1 mediated silencing of T-Cell Factor transcriptional activity

J Bou-Rouphael, M Doulazmi, A Eschstruth, A Abdou… - bioRxiv, 2023 - biorxiv.org
SUMMARY T-Cell Factors (TCFs) are the main transcriptional effectors of Wnt/β-catenin
signaling. TCF responsiveness is a hallmark of self-renewal in mouse embryonic, and adult …

The Role of Host Transcription Factor LEF1 in the Epstein-Barr Virus Life Cycle

BH Ward - 2023 - search.proquest.com
Epstein Barr virus (EBV) latency is associated with cancers of both B-lymphocyte and
epithelial cell origin. EBV life-cycle regulation requires the host epigenetic machinery …

[图书][B] Adult Mammalian Central Nervous System Regeneration

BP Lear - 2023 - search.proquest.com
When the mammalian central nervous system (CNS), the brain and spinal cord, is damaged
or degenerates, there is limited to no regeneration, leading to permanent and debilitating …

[PDF][PDF] Sex-dimorphic DNA methylation, isoform expression and WT1 binding during gonad development

T Gandhi - 2022 - ourarchive.otago.ac.nz
Mammalian sexual development hinges on sexually dimorphic genetic networks operating
within the embryonic gonads. These differential networks streamline development of the …