Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Metabolomics answers a fundamental question in biology: How does metabolism respond to
genetic, environmental or phenotypic perturbations? Combining several metabolomics …

Metabolomics is the qualitative and quantitative assessment of the metabolites (small
molecules< 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic …

African-American (AA) men are more likely to be diagnosed with and die from prostate
cancer than European American (EA) men. Despite the central role of the androgen receptor …

Prostate cancer (PCa) diagnosis with current biomarkers is difficult and often results in
unnecessary invasive procedures as well as over-diagnosis and over-treatment, highlighting …

Fixation of samples is broadly used prior to the histological evaluation of tissue samples.
Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry …

Diagnosis of prostate cancer is based on histologic evaluation of tumor architecture using a
system known as the “Gleason score.” This diagnostic paradigm, while the standard of care …

Gleason score, a measure of prostate tumor differentiation, is the strongest predictor of lethal
prostate cancer at the time of diagnosis. Metabolomic profiling of tumor and of patient serum …

Cancer cells hijack metabolic pathways to support bioenergetics and biosynthetic
requirements for their uncontrolled growth. Thus, cancer can be considered as a metabolic …