MAP kinases transduce signals that are involved in a multitude of cellular pathways and
functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate …

Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from
the primary tumor to distant organs. At the molecular level, migration is the result of several …

Polycystic kidney disease (ADPKD) results from failure of the kidney to properly maintain
three-dimensional structure after loss of either polycystin-1 or-2. Mice with kidney selective …

Abstract Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of
autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage …

SUMMARY Mutations in polycystin1 (PKD1) account for the majority of autosomal dominant
polycystic kidney disease (ADPKD). PKD1 mutations are also associated with vascular …

Polycystic kidney disease (PKD) is a genetic disorder that is characterized by cyst formation
in kidney tubules. PKD arises from abnormalities of the primary cilium, a sensory organelle …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose
dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has …

Polycystic kidney disease is typified by cysts in the kidney and extra-renal manifestations
including hypertension and heart failure. The main genetic underpinning this disease are …

Polycystic kidney disease is the most common heritable disease in humans. In addition to
epithelial cysts in the kidney, liver and pancreas, patients with autosomal dominant …