This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …

Background The effectiveness of the COVID-19 vaccination programme depends on mass
participation: the greater the number of people vaccinated, the less risk to the population …

The British Association for Psychopharmacology developed an evidence-based consensus
guideline on the management of catatonia. A group of international experts from a wide …

Objective: Research and clinical translation in schizophrenia is limited by inconsistent
definitions of treatment resistance and response. To address this issue, the authors …

Objectives: This guideline provides recommendations for the clinical management of
schizophrenia and related disorders for health professionals working in Australia and New …

Mental disorders are among the most common morbidities of pregnancy and the postnatal
period, and can have adverse effects on the mother, her child, and family. This Series paper …

Introduction Antipsychotic medications are mainstays in the treatment of schizophrenia and
a range of other psychotic disorders. Sources of data Recent meta-analyses of antipsychotic …

Objectives Existing treatments for schizophrenia can improve positive symptoms, but it is
unclear if they have any impact on negative symptoms. This meta-analysis was conducted to …

Treatment-resistant schizophrenia (TRS) represents a major clinical challenge. The broad
definition of TRS requires nonresponse to at least 2 sequential antipsychotic trials of …