The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Uniformly modified nucleic acids analogues, oligonucleotide N3′→ P5′
phosphoramidates, containing 3′-amino instead of 3′-hydroxyl nucleosides, were …

In an effort to discover novel oligonucleotide modifications for antisense therapeutics, we
have prepared oligodeoxyribonucleotides containing more than 200 different modifications …

Morpholino oligomers containing both uncharged and cationic intersubunit linkages are
provided. The oligomers are oligonucleotide analogs containing predetermined sequences …

The invention relates to compositions comprising oligomers antisense to bacterial 16S or
23S rRNA and capable of Selectively modulating the biological activity thereof, and methods …

Uniformly modified oligonucleotide N3′→ P5′ phosphoramidates, where every 3′-
oxygen is replaced by a 3′-amino group, were synthesized. These compounds have very …

A new class of oligonucleotide N3'→ P5'phosphoramidates having 2'fluoro substituents are
provided that have superior acid stability. The invention includes oligo-2'-fluoronucleotide …

In recent years, research in organophosphorus chemistry has mainly focused in designing
newer and better phosphorus ligands for synthesizing novel metal complexes with improved …

(57) ABSTRACT A method and composition for treating colorectal cancer is disclosed. The
method involves administering to a subject, a therapeutically effective amount of a …

Uniformly modified oligodeoxyribonucleotide N3′→ P5′ phosphoramidates containing
2′-fluoro-2′-deoxy-pyrimidine nucleosides were synthesized using an efficient interphase …