Rho kinase inhibitors (ROCKi) have attracted growing multidisciplinary interest, particularly
in Ophthalmology where the question as to how they promote corneal endothelial healing …

Intestinal epithelium functions as a tissue barrier to prevent interaction between the internal
compartment and the external milieu. Intestinal barrier function also determines epithelial …

Extracellular vesicles (EVs) are nanosized vesicles that act as snapshots of cellular
components and mediate cellular communications, but they may contain cargo contents with …

Semaphorins are a family of evolutionarily conserved morphogenetic molecules that were
initially found to be associated with axonal guidance. Semaphorin 4C (Sema4C), a member …

The generation of mature and vascularized human pluripotent stem cell-derived cardiac
organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease …

Background The oocyte development ability of prepubertal animals is significantly lower
than that of adult animals. Granulosa cells (GCs) have an important function on regulation of …

The Rho-associated coiled-coil containing kinases (ROCKs or Rho kinases) belong to the
AGC (PKA/PKG/PKC) family of serine/threonine kinases and are major downstream effectors …

Human induced pluripotent stem cells (hiPSCs) are an attractive cell source for regenerative
medicine. For its widespread use as a starting material, a robust storage and distribution …

Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process
eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In …

Fuch's Endothelial Corneal Dystrophy (FECD) is the leading cause of visually significant
corneal endothelial (CE) failure in Western countries3, estimated to affect 4% of the United …