Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has
resolved complex regions of the genome, including repetitive and homologous regions …

Understanding how the packaging of chromatin in the nucleus is regulated and organized to
guide complex cellular and developmental programmes, as well as responses to …

Across species, sperm maturation involves the dramatic reconfiguration of chromatin into
highly compact nuclei that enhance hydrodynamic ability and ensure paternal genomic …

Although rapid evolution of pericentromeric satellite DNA repeats is theorized to promote
hybrid incompatibility (HI)(;;;;), how divergent repeats affect hybrid cells remains poorly …

Background The last decade witnessed a number of genome-wide studies on human pre-
implantation, which mostly focused on genes and provided only limited information on …

Heterochromatic condensates (chromocenters) are critical for maintaining the silencing of
heterochromatin. It is therefore puzzling that the presence of chromocenters is variable …

Constitutive heterochromatin at the pericentric regions of chromosomes undergoes dynamic
changes in its epigenetic and spatial organization during spermatogenesis. Accurate control …

The centromere is the chromosomal locus essential for proper chromosome segregation.
While the centromeric function is well conserved and epigenetically specified, centromeric …

(Peri) centromeric repetitive sequences and, more specifically, satellite DNA (satDNA)
sequences, constitute a major human genomic component. SatDNA sequences can vary on …