Convertible and Constrained Nucleotides: The 2'-Deoxyribose 5'-C-Functionalization Approach, a French Touch
C Chardet, C Payrastre, B Gerland, JM Escudier - Molecules, 2021 - mdpi.com
Many strategies have been developed to modulate the biological or biotechnical properties
of oligonucleotides by introducing new chemical functionalities or by enhancing their affinity …
of oligonucleotides by introducing new chemical functionalities or by enhancing their affinity …
Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′, 4′-Tetrahydropyran …
T Osawa, T Akino, S Obika - The Journal of Organic Chemistry, 2023 - ACS Publications
Replacement of a phosphodiester linkage with an amide linkage can improve the binding
affinity of oligonucleotides to complementary RNA and their stability toward nucleases. In …
affinity of oligonucleotides to complementary RNA and their stability toward nucleases. In …
Synthesis and structural analysis of dinucleotides containing 2′, 3′-trans-bridged nucleic acids (2′, 3′-trans-BNAs) with trans-5, 6-or 5, 7-fused ring skeleton
S Obika, T Osawa, R Nakasishi - 2024 - researchsquare.com
Artificial nucleic acids in which the conformation of the sugar or phosphate backbone of the
oligonucleotide is appropriately fixed can form stable duplexes. In this study, we designed …
oligonucleotide is appropriately fixed can form stable duplexes. In this study, we designed …
Convertible and conformationally constrained nucleic acids (C 2 NAs)
JM Escudier, C Payrastre, B Gerland… - Organic & Biomolecular …, 2019 - pubs.rsc.org
We introduce the concept of Convertible and Constrained Nucleic Acids (C2NAs). By means
of the synthesis of a stereocontrolled N-propargyl dioxo-1, 3, 2-oxaza-phosphorinane as an …
of the synthesis of a stereocontrolled N-propargyl dioxo-1, 3, 2-oxaza-phosphorinane as an …