The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

Mast cells and basophils represent the most relevant source of histamine in the immune
system. Histamine is stored in cytoplasmic granules along with other amines (eg, serotonin) …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively
expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress …

Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In
the steady-state, IL-33 is expressed in the nucleus of epithelial, endothelial, and fibroblast …

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation,
predominantly affecting the lung parenchyma and peripheral airways, that results in …

IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the
nucleus of epithelial cells and released into the extracellular space following tissue damage …

Background The alarmin cytokines IL-25 and IL-33 are key promoters of type 2 inflammation.
Basophils respond to alarmin cytokines, however the relationship of these cytokines with …

The β common chain (βc) cytokine family includes granulocyte-macrophage colony-
stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5, all of which use βc as key …

Objectives Mast cells (MCs) are involved in the pathogenesis of rheumatoid arthritis (RA).
However, their contribution remains controversial. To establish their role in RA, we analysed …