Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …

Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …

Certain retroviruses, including HIV, insert their DNA in a non-random fraction of the host
genome via poorly understood selection mechanisms. Here, we develop a biophysical …

During their lifecycle, bacteria are exposed to continuous changes in their environment,
some of which are stressful and can be harmful. The cell envelope is the first line of defense …

Background Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by
the cellular transcription machinery. This process is regulated by both viral and cellular …

Background Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This
step is modulated by chromatin structure as nucleosomes compaction was shown to prevent …

ABSTRACT HIV-1 DNA is preferentially integrated into chromosomal hot spots by the
preintegration complex (PIC). To understand the mechanism, we measured the DNA …

Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two
essential steps of their viral replication: reverse transcription and integration. This latter …

One of the most crucial steps in the life cycle of a retrovirus is the integration of the viral DNA
(vDNA) copy of the RNA genome into the genome of an infected host cell. Integration …