Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …
eukaryotes that has important implications for normal biology and disease. Therefore …
Recent advances in biosensors for in vitro detection and in vivo imaging of DNA methylation
Q Zhang, Y Wu, Q Xu, F Ma, C Zhang - Biosensors and Bioelectronics, 2021 - Elsevier
DNA methylation is the predominant epigenetic modification that participates in many
fundamental cellular processes through posttranscriptional regulation of gene expression …
fundamental cellular processes through posttranscriptional regulation of gene expression …
CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors
LA Kalekar, SE Schmiel, SL Nandiwada, WY Lam… - Nature …, 2016 - nature.com
The role of anergy, an acquired state of T cell functional unresponsiveness, in natural
peripheral tolerance remains unclear. In this study, we found that anergy was selectively …
peripheral tolerance remains unclear. In this study, we found that anergy was selectively …
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail
Y Zhang, R Jurkowska, S Soeroes… - Nucleic acids …, 2010 - academic.oup.com
Using peptide arrays and binding to native histone proteins, we show that the ADD domain
of Dnmt3a specifically interacts with the H3 histone 1–19 tail. Binding is disrupted by di-and …
of Dnmt3a specifically interacts with the H3 histone 1–19 tail. Binding is disrupted by di-and …
Dual methylation-sensitive restriction endonucleases coupling with an RPA-assisted CRISPR/Cas13a system (DESCS) for highly sensitive analysis of DNA …
X Wang, S Zhou, C Chu, M Yang, D Huo, C Hou - ACS sensors, 2021 - ACS Publications
High-performance detection of DNA methylation possesses great significance for the
diagnosis and therapy of cancer. Herein, for the first time, we present a digestion strategy …
diagnosis and therapy of cancer. Herein, for the first time, we present a digestion strategy …
BISMA-Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Background Bisulfite sequencing is a popular method to analyze DNA methylation patterns
at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA …
at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA …
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a–Dnmt3L single-chain fusion protein with increased DNA methylation …
AN Siddique, S Nunna, A Rajavelu, Y Zhang… - Journal of molecular …, 2013 - Elsevier
The C-terminal domain of the Dnmt3a de novo DNA methyltransferase (Dnmt3a-C) forms a
complex with the C-terminal domain of Dnmt3L, which stimulates its catalytic activity. We …
complex with the C-terminal domain of Dnmt3L, which stimulates its catalytic activity. We …
Endocardial fibroelastosis is caused by aberrant endothelial to mesenchymal transition
X Xu, I Friehs, T Zhong Hu, I Melnychenko… - Circulation …, 2015 - Am Heart Assoc
Rationale: Endocardial fibroelastosis (EFE) is a unique form of fibrosis, which forms a de
novo subendocardial tissue layer encapsulating the myocardium and stunting its growth …
novo subendocardial tissue layer encapsulating the myocardium and stunting its growth …
Potential forensic application of DNA methylation profiling to body fluid identification
HY Lee, MJ Park, A Choi, JH An, WI Yang… - International journal of …, 2012 - Springer
DNA analysis of various body fluid stains at crime scenes facilitates the identification of
individuals but does not currently determine the type and origin of the biological material …
individuals but does not currently determine the type and origin of the biological material …
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution
Y Zhang, C Rohde, S Tierling, TP Jurkowski… - PLoS …, 2009 - journals.plos.org
Differential DNA methylation is an essential epigenetic signal for gene regulation,
development, and disease processes. We mapped DNA methylation patterns of 190 gene …
development, and disease processes. We mapped DNA methylation patterns of 190 gene …