Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …

Introduction Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies
compared with the general population. This has raised concerns regarding these patients …

Background & Aims Thiopurine therapy for inflammatory bowel disease (IBD) has been
associated with increased risk for lymphoma. We estimated the relative risk of lymphoma in …

The human immune system involves highly complex and coordinated processes in which
small proteins named cytokines play a key role. Cytokines have been implicated in the …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Objective To compare the efficacy and safety of adalimumab plus methotrexate (MTX)
versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Background The risk of development of non-Hodgkin lymphoma (NHL) in autoimmune
patients has been investigated in several cohort studies. These studies revealed …

Objective Chronic inflammatory conditions such as rheumatoid arthritis (RA) have been
associated with malignant lymphomas. This study was undertaken to investigate which …

Background Helicobacter pylori infection, now considered to be a cause of gastric cancer, is
also strongly associated with gastric and duodenal ulcer disease. The discovery of these …