Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Background The distinction between unilateral aldosterone-producing adenoma or bilateral
adrenal hyperplasia as causes of primary aldosteronism is usually made by adrenal CT or …

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

Context Somatic mutations have been identified in more than half of aldosterone-producing
adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of …

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in
genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Background: Both aging and inappropriate secretion of aldosterone increase the risk for
developing cardiovascular disease; however, the influence of aging on aldosterone …

Primary aldosteronism comprises 2 main subtypes: unilateral aldosterone-producing
adenoma (APA) and bilateral adrenal hyperplasia. Somatic KCNJ5 mutations are found in …