The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Abstract Interleukin-6 (IL-6) is a major cytokine that promotes anti-and pro-inflammatory
outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL …

Abstract Cytokines, particularly IL-6, play a crucial role in modulating immune responses in
the central nervous system (CNS). Elevated IL-6 levels have been observed in …

The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the
biological impact of this cytokine in health and disease. With broad activities affecting the …

For most, staying “mentally sharp” as they age is a very high priority that may be thwarted by
the consequences of a postoperative complication unrelated to the disorder which …

The temporal course and the severity of the involution of sensory systems through aging can
be critical since they ensure the ability to perceive and recognize the world. In older people …

From inadequate prior antidepressants that targeted monoamine neurotransmitter systems
emerged the discovery of alternative drugs for depression. For instance, drugs targeted …

Maternal obesity greatly affects next generations, elevating obesity risk in the offspring
through perinatal programming and flawed maternal and newborn nutrition. The exact …

Psychological stress predisposes our body to several disorders. Understanding the cellular
and molecular mechanisms involved in the physiological responses to psychological stress …

Background: Numerous mouse models of Alzheimer's disease (AD) are available, but all
suffer from certain limitations, thus prompting further attempts. To date, no one model exists …