Background Vascular contributions to cognitive impairment and dementia (VCID) is a
complex form of dementia, combining aspects of vascular disease and other forms of …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene and is …

Parkinson disease (PD), progressive supranuclear palsy (PSP), and multiple-system atrophy
(MSA) are known to affect dopaminergic neurons of the brain stem and striatum with different …

BACKGROUND AND PURPOSE: MSA-P and IPD have similar clinical presentations that
may complicate accurate clinical diagnosis. Different iron-deposition patterns of those 2 …

Migraine with aura is often the first manifestation of cerebral autosomal dominant
arteriopathy with subcortical infarcts and leukoencephalopathy syndrome (CADASIL), a …

BACKGROUND AND PURPOSE: Loss of dopaminergic neurons in the nigrostriatal pathway
is well-documented in PD, whereas neuronal changes beyond the nigrostriatal pathway are …

Dementia is a major cause of disability and dependency among older people. If the lives of
people with dementia are to be improved, research and its translation into druggable target …

Abstract Background: Friedrich Nietzsche (1844-1900), one of the most profound and
influential modern philosophers, suffered since his very childhood from severe migraine. At …

The understanding of the genetic basis of neurological disorders has grown rapidly in the
last two decades. Despite the genomic heterogeneity within African populations, large-scale …

Background Differences have been noted in the clinical presentation and mutational
spectrum of CADASIL among various geographical areas. The aim of the present study was …