Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes

E Cowan, KJ Burch, BD Green… - British Journal of …, 2016 - Wiley Online Library
Obestatin is a 23‐amino acid C‐terminally amidated gastrointestinal peptide derived from
preproghrelin and which forms an α helix. Although obestatin has a short biological half‐life …

The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease

I Seim, C Walpole, L Amorim, P Josh… - Molecular and cellular …, 2011 - Elsevier
Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the
stomach and a range of other tissues throughout the body. While it was initially reported that …

Biochemical properties and biological actions of obestatin and its relevence in type 2 diabetes

BD Green, DJ Grieve - Peptides, 2018 - Elsevier
Obestatin was initially discovered in rat stomach extract, and although it is principally
produced in the gastric mucosa, it can be found throughout the gastrointestinal tract. This 23 …

Chronic treatment with a stable obestatin analog significantly alters plasma triglyceride levels but fails to influence food intake; fluid intake; body weight; or body …

A Agnew, D Calderwood, OP Chevallier, B Greer… - Peptides, 2011 - Elsevier
Obestatin (OB (1-23) is a 23 amino acid peptide encoded on the preproghrelin gene,
originally reported to have metabolic actions related to food intake, gastric emptying and …

Obestatin and rosiglitazone differentially modulate lipid metabolism through peroxisome proliferator-activated receptor-γ (PPARγ) in pre-adipose and mature 3T3-L1 …

M BG, UV Manjappara - Cell Biochemistry and Biophysics, 2021 - Springer
Obestatin is a 23-residue peptide, obtained after posttranslational modification of
preproghrelin. It has been shown, in Swiss albino mice, to upregulate glycerolipid …

Capsaicin and genistein override the Action of obestatin to decrease lipid accumulation in 3T3-L1 cells

MSK Reddy, UV Manjappara - Cell biochemistry and biophysics, 2019 - Springer
Satiety peptides convey information about short-term energy reserves in the gut to the
hypothalamus and aid in regulation of appetite and food intake. Obestatin is one such gastro …

Metabolic and structural properties of human obestatin {1–23} and two fragment peptides

AP Subasinghage, BD Green, PR Flatt, N Irwin… - Peptides, 2010 - Elsevier
Obestatin is a peptide produced in the oxyntic mucosa of the stomach and co-localizes with
ghrelin on the periphery of pancreatic islets. Several studies demonstrate that obestatin …

Peripheral administration of TAT-obestatin can influence the expression of liporegulatory genes but fails to affect food intake in mice

G Ren, Z He, P Cong, H Chen, Y Guo, J Yu, Z Liu, Q Ji… - Peptides, 2013 - Elsevier
Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor.
However, most of the subsequent studies failed to confirm the initially reported anorexigenic …

Obestatin and Nt8U influence glycerolipid metabolism and PPAR gamma signaling in mice

SR Nagaraj, AV Raghavan, SN Rao… - The international journal …, 2014 - Elsevier
Obestatin, its N-terminal fragment and the N-terminal fragment analog Nt8U were previously
shown to reduce food intake, gain in body weight and triglyceride levels in albino mice. To …

Serum ghrelin, but not obestatin, is a potential predictor of acute pancreatitis severity

H Wang, M Qin, Z Liang, R Chang, H Fu, Y Wei… - Medicine, 2017 - journals.lww.com
The roles of ghrelin and obestatin in AP remain controversial. This study investigates the
effects and the predictive value of serum ghrelin and obestatin levels in the early stage of …