The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …

Molecular medicine has entered a high-tech age that provides curative treatments of
complex genetic diseases through genetically engineered cellular medicinal products. Their …

Baculoviruses are insect pathogens widely used as biotechnological tools in different fields
of life sciences and technologies. The particular biology of these entities (biosafety viruses 1; …

Sleeping Beauty (SB) is the first synthetic DNA transposon that was shown to be active in a
wide variety of species. Here, we review studies from the last two decades addressing both …

Baculovirus is an insect virus which has been used for more than thirty years for production
of recombinant proteins in insect cells. However, baculovirus can also be harnessed for …

Gene therapies hold significant promise for treating previously incurable diseases. A
number of gene therapies have already been approved for clinical use. Currently, gene …

Baculovirus is an obligate parasitic virus of the phylum Arthropoda. Baculovirus including
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely used in …

Delivery and expression of recombinant genes, a key methodology for many applications in
biological research, remains a challenge especially for mature neurons. Here, we report …

For efficient delivery of required genetic elements we utilized high-capacity adenoviral
vectors in the past allowing high transgene capacities of up to 36 kb. Previously we explored …

MicroRNA 122 (miR-122) is a tumor suppressor for hepatocellular carcinoma (HCC) but is
lowly expressed in HCC cells. MiR-151 is aberrantly overexpressed in HCC cells and …