IL-1 family members have multiple pleiotropic functions affecting various tissues and cells,
including the regulation of the immune response, hematopoietic homeostasis, bone …

Osteosarcoma (OS) is a prevalent and highly malignant bone tumor, characterized by its
aggressive nature, invasiveness, and rapid progression, contributing to a high mortality rate …

Introduction Osteosarcoma is a common type of bone cancer characterized by a poor
prognosis due to its metastatic nature. The tumor microenvironment (TME) plays a critical …

Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have
abysmal five-year overall survival rates. The complexity of the osteosarcoma immune tumor …

Osteosarcoma is the most common primary bone malignancy, with a very poor prognosis.
Aberrant glycosylation is close involvement in osteosarcoma. Accordingly, this study aimed …

Small extracellular vesicles (sEVs) are important mediators of intercellular communication
between tumor cells and their surrounding environment. Furthermore, the mechanisms by …

Gene therapy is an efficacious therapeutic modality for triple negative breast cancer (TNBC).
However, the practicable applicability is strictly confined in TNBC-associated metastatic …

CD47 is expressed on cell surfaces and acts as a “don't eat me” signal by interacting with
signal-regulatory protein-α on the macrophage surface. Some cancer cells express CD47 …

Immunosuppressive elements within the tumor microenvironment are the primary drivers of
tumorigenesis and malignant advancement. The presence, as well as the crosstalk between …

Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the
intricate interactions within its tumor microenvironment (TME), particularly involving …