Global view of human protein glycosylation pathways and functions
Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …
Recent developments in bioprocessing of recombinant proteins: expression hosts and process development
NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …
humans worldwide. The production of therapeutic proteins for treating diseases at large …
An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity
Plants sense abscisic acid (ABA) using chemical-induced dimerization (CID) modules,
including the receptor PYR1 and HAB1, a phosphatase inhibited by ligand-activated PYR1 …
including the receptor PYR1 and HAB1, a phosphatase inhibited by ligand-activated PYR1 …
Genetic glycoengineering in mammalian cells
Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …
Bioprocess systems analysis, modeling, estimation, and control
The production of monoclonal antibody (mAb) therapeutics, a rapidly growing multi-billion-
dollar enterprise in the biopharmaceutical industry, faces major challenges in achieving …
dollar enterprise in the biopharmaceutical industry, faces major challenges in achieving …
Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
RQ Wu, XM Lao, DP Chen, H Qin, M Mu, WJ Cao… - Immunity, 2023 - cell.com
The reinvigoration of anti-tumor T cells in response to immune checkpoint blockade (ICB)
therapy is well established. Whether and how ICB therapy manipulates antibody-mediated …
therapy is well established. Whether and how ICB therapy manipulates antibody-mediated …
Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads
Y Park, A Espah Borujeni, TE Gorochowski… - Molecular systems …, 2020 - embopress.org
Genetic circuits have many applications, from guiding living therapeutics to ordering process
in a bioreactor, but to be useful they have to be genetically stable and not hinder the host …
in a bioreactor, but to be useful they have to be genetically stable and not hinder the host …
Glycan-mediated molecular interactions in bacterial pathogenesis
Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly,
glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host …
glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host …
N-Glycosylation
T Hirata, Y Kizuka - The role of glycosylation in health and disease, 2021 - Springer
N-glycosylation is a highly conserved glycan modification, and more than 7000 proteins are
N-glycosylated in humans. N-glycosylation has many biological functions such as protein …
N-glycosylated in humans. N-glycosylation has many biological functions such as protein …
Artificial intelligence in the analysis of glycosylation data
Glycans are complex, yet ubiquitous across biological systems. They are involved in diverse
essential organismal functions. Aberrant glycosylation may lead to disease development …
essential organismal functions. Aberrant glycosylation may lead to disease development …