Mechanisms and regulation of cholesterol homeostasis

J Luo, H Yang, BL Song - Nature reviews Molecular cell biology, 2020 - nature.com
Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

[HTML][HTML] Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

Mechanisms of foam cell formation in atherosclerosis

DA Chistiakov, AA Melnichenko… - Journal of molecular …, 2017 - Springer
Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review

R Navickas, D Gal, A Laucevičius… - Cardiovascular …, 2016 - academic.oup.com
The aim of the present study is to identify microRNAs (miRs) with high potential to be used
as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis …

[HTML][HTML] Long non-coding RNA structure and function: is there a link?

A Zampetaki, A Albrecht, K Steinhofel - Frontiers in physiology, 2018 - frontiersin.org
RNA has emerged as the prime target for diagnostics, therapeutics and the development of
personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode …

[HTML][HTML] Role of microRNAs in obesity and obesity-related diseases

G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Macrophage deficiency of miR‐21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis

A Canfrán‐Duque, N Rotllan, X Zhang… - EMBO molecular …, 2017 - embopress.org
Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory
disease characterized by the accumulation of lipids and inflammatory cells in the artery wall …

Brothers in arms: ABCA1-and ABCG1-mediated cholesterol efflux as promising targets in cardiovascular disease treatment

SJCM Frambach, R de Haas, JAM Smeitink… - Pharmacological …, 2020 - ASPET
Atherosclerosis is a leading cause of cardiovascular disease worldwide, and
hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on the …

[HTML][HTML] Advances in cardiovascular biomarker discovery

CM Ghantous, L Kamareddine, R Farhat, FA Zouein… - Biomedicines, 2020 - mdpi.com
Cardiovascular diseases are the leading causes of mortality worldwide. Among them,
hypertension and its pathological complications pose a major risk for the development of …

[HTML][HTML] Exosomes of pasteurized milk: potential pathogens of Western diseases

BC Melnik, G Schmitz - Journal of translational medicine, 2019 - Springer
Milk consumption is a hallmark of western diet. According to common believes, milk
consumption has beneficial effects for human health. Pasteurization of cow's milk protects …